Replaces Prod. #: ALX-340-001
AACOCF3 is a trifluoromethylketone derivative of arachidonic acid. It is a selective inhibitor of human cytosolic PLA2 and Ca2+-independent PLA2 (iPLA2, IC50=15 µM). It is active in intact platelets and U937 cells (IC50=8 µM). It also inhibits fatty acid amide hydrolase (100% at 7.5 µM).
Product Details
| Formula: | C21H31F3O |
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| MW: | 356.5 |
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| CAS: | 149301-79-1 |
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| Purity: | ≥98% (TLC) |
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| Identity: | Determined by NMR. |
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| Appearance: | Yellow oil. |
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| Solubility: | Soluble in DMSO (>25mg/ml) or 100% ethanol (>25mg/ml). |
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| Shipping: | Dry Ice |
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| Long Term Storage: | -80°C |
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| Use/Stability: | Solutions are stable for up to 1 month when stored under nitrogen or argon in tightly sealed container at -80°C. |
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| Handling: | Protect from air. Dissolve in solvent purged with nitrogen or argon. Store under nitrogen or argon in tightly sealed container. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Leukotriene D4-induced CaCo-2 cell proliferation is mediated by prostoglandin E2 synthesis: M. Cabral, et al.; Physiol. Rep.
3, e12417 (2015),
Application(s): Cell culture ,
Abstract;
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Inhibition of macrophage Ca(2+)-independent phospholipase A2 by bromoenol lactone and trifluoromethyl ketones: E.J. Ackermann, et al.; J. Biol. Chem.
270, 445 (1995),
Abstract;
Arachidonyl trifluoromethyl ketone, a potent inhibitor of 85-kDa phospholipase A2, blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets: D. Riendeau, et al.; J. Biol. Chem.
269, 15619 (1994),
Abstract;
Inhibitors of arachidonoyl ethanolamide hydrolysis: B. Koutek, et al.; J. Biol. Chem.
269, 22937 (1994),
Abstract;
Tight binding inhibitors of 85-kDa phospholipase A2 but not 14-kDa phospholipase A2 inhibit release of free arachidonate in thrombin-stimulated human platelets: F. Bartoli, et al.; J. Biol. Chem.
269, 15625 (1994),
Abstract;
Slow- and tight-binding inhibitors of the 85-kDa human phospholipase A2: I.P. Street, et al.; Biochemistry
32, 5935 (1993),
Abstract;
