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Inhibitor of PLA2 and FAAH
BML-ST335-0010 10 mg 114.00 USD
BML-ST335-0050 50 mg 334.00 USD
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Replaces Prod. #: ALX-340-001

AACOCF3 is a trifluoromethylketone derivative of arachidonic acid. It is a selective inhibitor of human cytosolic PLA2 and Ca2+-independent PLA2 (iPLA2, IC50=15 µM). It is active in intact platelets and U937 cells (IC50=8 µM). It also inhibits fatty acid amide hydrolase (100% at 7.5 µM).

Product Specification

Purity:≥98% (TLC)
Identity:Determined by NMR.
Appearance:Yellow oil.
Solubility:Soluble in DMSO (>25mg/ml) or 100% ethanol (>25mg/ml).
Shipping:Shipped on Dry Ice
Long Term Storage:-80°C
Use/Stability:Solutions are stable for up to 1 month when stored under nitrogen or argon in tightly sealed container at -80°C.
Handling:Protect from air. Dissolve in solvent purged with nitrogen or argon. Store under nitrogen or argon in tightly sealed container.
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Product Literature References

Leukotriene D4-induced CaCo-2 cell proliferation is mediated by prostoglandin E2 synthesis: M. Cabral, et al.; Physiol. Rep. 3, e12417 (2015), Application(s): Cell culture , Abstract; Full Text
Inhibition of macrophage Ca(2+)-independent phospholipase A2 by bromoenol lactone and trifluoromethyl ketones: E.J. Ackermann, et al.; J. Biol. Chem. 270, 445 (1995), Abstract;
Arachidonyl trifluoromethyl ketone, a potent inhibitor of 85-kDa phospholipase A2, blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets: D. Riendeau, et al.; J. Biol. Chem. 269, 15619 (1994), Abstract;
Inhibitors of arachidonoyl ethanolamide hydrolysis: B. Koutek, et al.; J. Biol. Chem. 269, 22937 (1994), Abstract;
Tight binding inhibitors of 85-kDa phospholipase A2 but not 14-kDa phospholipase A2 inhibit release of free arachidonate in thrombin-stimulated human platelets: F. Bartoli, et al.; J. Biol. Chem. 269, 15625 (1994), Abstract;
Slow- and tight-binding inhibitors of the 85-kDa human phospholipase A2: I.P. Street, et al.; Biochemistry 32, 5935 (1993), Abstract;

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