AACOCF3

Inhibitor of PLA₂ and FAAH



BML-ST335-0010	10 mg	93.00 USD

BML-ST335-0050	50 mg	272.00 USD

Replaces Prod. #: ALX-340-001

AACOCF₃ is a trifluoromethylketone derivative of arachidonic acid. It is a selective inhibitor of human cytosolic PLA₂ and Ca²⁺-independent PLA₂ (iPLA₂, IC₅₀=15 µM). It is active in intact platelets and U937 cells (IC₅₀=8 µM). It also inhibits fatty acid amide hydrolase (100% at 7.5 µM).

Product Specification

Formula:	C₂₁H₃₁F₃O

MW:	356.5

Purity:	≥98% (TLC)

Appearance:	Yellow oil.

CAS:	149301-79-1

Solubility:	Soluble in DMSO (>25mg/ml) or 100% ethanol (>25mg/ml).

Long Term Storage:	-80°C

Use/Stability:	Dissolve in solvent purged with nitrogen or argon. Store under nitrogen or argon in tightly sealed container. Solutions are stable for up to 1 month when stored under nitrogen or argon in tightly sealed container at -80°C.

Handling:	Protect from air.

Background / Technical Information:	Please click here for the comprehensive product datasheet.

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Product Literature References

Inhibition of macrophage Ca(2+)-independent phospholipase A2 by bromoenol lactone and trifluoromethyl ketones: E.J. Ackermann, et al.; J. Biol. Chem. 270, 445 (1995), Abstract;

Arachidonyl trifluoromethyl ketone, a potent inhibitor of 85-kDa phospholipase A2, blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets: D. Riendeau, et al.; J. Biol. Chem. 269, 15619 (1994), Abstract;

Inhibitors of arachidonoyl ethanolamide hydrolysis: B. Koutek, et al.; J. Biol. Chem. 269, 22937 (1994), Abstract;

Tight binding inhibitors of 85-kDa phospholipase A2 but not 14-kDa phospholipase A2 inhibit release of free arachidonate in thrombin-stimulated human platelets: F. Bartoli, et al.; J. Biol. Chem. 269, 15625 (1994), Abstract;

Slow- and tight-binding inhibitors of the 85-kDa human phospholipase A2: I.P. Street, et al.; Biochemistry 32, 5935 (1993), Abstract;