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Phospholipase inhibitor
BML-ST330-0005 5 mg 80.00 USD
BML-ST330-0025 25 mg 318.00 USD
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Replaces Prod. #: ALX-270-089

Selective inhibitor of phosphatidylcholine-specific phospholipase C (PC-PLC). Has been used to study the coupling of phosphatidylcholine-specific phospholipase C with sphingomyelinase. Shows antitumor and antiviral activity. Inhibits basement membrane collagen synthesis, which is the last step in the development of a new blood vessel. Inhibits induction of nitric oxide synthases (NOS). Induces apoptosis. It indirectly inhibits phorbol ester stimulated PLD activity.

Product Specification

Alternative Name:Tricyclodecan-9-yl xanthogenate . K
Formula:C11H15OS2 . K
Purity:≥98% (TLC)
Appearance:Off-white solid.
Solubility:Soluble in water (25mg/ml).
Long Term Storage:-20°C
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at -20°C. We recommend to prepare fresh solutions each day.
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Product Literature References

D609 blocks cell survival and induces apoptosis in neural stem cells: N. Wang, et al.; Bioorg. Med. Chem. Lett. 16, 4780 (2006), Abstract;
Protection against amyloid beta-peptide (1-42)-induced loss of phospholipid asymmetry in synaptosomal membranes by tricyclodecan-9-xanthogenate (D609) and ferulic acid ethyl ester: implications for Alzheimer´s disease: H. Mohmmad Abdul & D.A. Butterfield; Biochim. Biophys. Acta 1741, 140 (2005), Abstract;
Two distinct Fas-activated signaling pathways revealed by an antitumor drug D609: L. Zhang, et al.; Oncogene 24, 2954 (2005), Abstract;
Protective effect of the xanthate, D609, on Alzheimer´s amyloid beta-peptide (1-42)-induced oxidative stress in primary neuronal cells: R. Sultana, et al.; Free Radic. Res. 38, 449 (2004), Abstract;
Sphingomyelin synthase as a potential target for D609-induced apoptosis in U937 human monocytic leukemia cells: A. Meng, et al.; Exp. Cell Res. 292, 385 (2004), Abstract;
Synthesis and phospholipase C inhibitory activity of D609 diastereomers: A. Gonzalez-Roura, et al.; Lipids 37, 401 (2002), Abstract;
D609 inhibits ionizing radiation-induced oxidative damage by acting as a potent antioxidant: D. Zhou, et al.; J. Pharmacol. Exp. Ther. 298, 103 (2001), Abstract; Full Text
D609-sensitive tyrosine phosphorylation is involved in Fas-mediated phospholipase D activation: J.G. Kim, et al.; Exp. Mol. Med. 33, 303 (2001), Abstract; Full Text
D609-phosphatidylcholine-specific phospholipase C inhibitor attenuates thapsigargin-induced sodium influx in human lymphocytes: J.R. Nofer, et al.; Cell Signal. 12, 289 (2000), Abstract;
A phosphatidylcholine phospholipase C inhibitor, D609, blocks interleukin-3 (IL-3)-induced bcl-2 expression but not c-myc expression in human IL-3-dependent cells: R.A. Mufson, et al.; Exp. Cell Res. 240, 228 (1998), Abstract;
Phosphatidylcholine-specific phospholipase inhibitor D609 differentially affects MAP kinases and immediate-early genes in PC12 cells: P.J. Kahle, et al.; Cell Signal. 10, 321 (1998), Abstract;
Stimulation of DNA synthesis in untransformed cells by the antiviral and antitumoral compound tricyclodecan-9-yl-xanthogenate (D609): Z. Kiss, et al.; Biochem. Pharmacol. 55, 915 (1998), Abstract;
Induction of apoptosis and potentiation of TNF- and Fas-mediated apoptosis in U937 cells by the xanthogenate compound D609: M.I. Porn-Ares, et al.; Exp. Cell Res. 235, 48 (1997), Abstract;
Prevention of experimental allergic encephalomyelitis by targeting nitric oxide and peroxynitrite: implications for the treatment of multiple sclerosis: D.C. Hooper, et al.; PNAS 94, 2528 (1997), Abstract; Full Text
The antiviral xanthate compound D609 inhibits herpes simplex virus type 1 replication and protein phosphorylation: D.G. Walro & K.S. Rosenthal; Antiviral Res. 36, 63 (1997), Abstract;
Compound D609 inhibits phorbol ester-stimulated phospholipase D activity and phospholipase C-mediated phosphatidylethanolamine hydrolysis: Z. Kiss & M. Tomono; Biochim. Biophys. Acta 1259, 105 (1995), Abstract;
Induction of nitric oxide synthase activity in phagocytic cells inhibited by tricyclodecan-9-yl-xanthogenate (D609): K. Tschaikowsky, et al.; Br. J. Pharmacol. 113, 664 (1994), Abstract;
Inhibitors of basement membrane collagen synthesis prevent endothelial cell alignment in matrigel in vitro and angiogenesis in vivo: G.C. Haralabopoulos, et al.; Lab. Invest. 71, 575 (1994), Abstract;
Hydrolysis of phosphatidylcholine couples Ras to activation of Raf protein kinase during mitogenic signal transduction: H. Cai, et al.; Mol. Cell Biol. 13, 7645 (1993), Abstract;
TNF activates NF-kappa B by phosphatidylcholine-specific phospholipase C-induced "acidic" sphingomyelin breakdown: S. Schütze, et al.; Cell 71, 765 (1992), Abstract;
Interruption of TPA-induced signals by an antiviral and antitumoral xanthate compound: inhibition of a phospholipase C-type reaction: K. Muller-Decker; BBRC 162, 198 (1989), Abstract;
Interruption of growth signal transduction by an antiviral and antitumoral xanthate compound: K. Muller-Decker, et al.; Exp. Cell. Res. 177, 295 (1988), Abstract;
DNA and RNA virus species are inhibited by xanthates, a class of antiviral compounds with unique properties: G. Sauer, et al.; PNAS 81, 3263 (1984), Abstract;

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