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Phospholipase inhibitor
BML-ST320-0020 20 mg 79.00 USD
BML-ST320-0100 100 mg 324.00 USD
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Replaces Prod. #: ALX-270-115

Phospholipase A2 inhibitor (IC50=7 µM for purified guinea pig lung PLA2). Inhibits epinephrine-stimulated thromboxane production in human platelets (86% at 3.5µM). Also blocks insulin secretion in pancreatic islets in response to glucose. Disrupts membrane tubule-mediated reassembly and maintenance of the Golgi complex.

Product Specification

Alternative Name:2-(p-Amylcinnamoyl)amino-4-chlorobenzoic acid
Purity:≥98% (TLC)
Appearance:Off-white to yellow solid.
Solubility:Soluble in DMSO (25mg/ml, warm) or 100% ethanol (10mg/ml, warm).
Long Term Storage:Ambient
Use/Stability:Stable for at least 2 years after receipt when stored at +20°C. Stock solutions are stable for up to 3 months at -20°C.
Handling:Protect from light. Do not freeze.
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Product Literature References

Regulation of the water channel aquaporin-1: isolation and reconstitution of the regulatory complex: R. Abu-Hamdah, et al.; Cell Biol. Int. 28, 7 (2004), Abstract;
Membrane tubule-mediated reassembly and maintenance of the Golgi complex is disrupted by phospholipase A2 antagonists: P. de Figueiredo, et al.; Mol. Biol. Cell 10, 1763 (1999), Abstract;
Effect of phospholipase A2 inhibitor ONO-RS-082 on substance P-induced histamine release from rat peritoneal mast cells: M. Kurosawa, et al.; Int. Arch. Allergy Immunol. 97, 226 (1992), Abstract;
Inhibition of phospholipase A2 and insulin secretion in pancreatic islets: R.J. Konrad, et al.; Biochim. Biophys. Acta 1135, 215 (1992), Abstract;
Activation of phospholipases A and C in human platelets exposed to epinephrine: role of glycoproteins IIb/IIIa and dual role of epinephrine: H.S. Banga, et al.; PNAS 83, 9197 (1986), Abstract;

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