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Phospholipase inhibitor
BML-ST310-0001 1 mg 144.00 USD
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Replaces Prod. #: ALX-350-038

Marine sesterterpenoid. Structurally related to manoalide (Prod. No. BML-EI177). Anti-inflammatory phospholipase A2 (PLA2) inhibitor (IC50=0.23µM). Less potent than manoalide, but partially reversible (IC50=0.23µM, bee venom PLA2). Inhibits human recombinant sPLA2 (IC50=9.3µM) selectively over cPLA2.

Product Specification

Source:Isolated from sponge Luffariella sp.
Purity:≥98% (TLC)
Appearance:Pale yellow oil.
Solubility:Soluble in DMSO or 100% ethanol.
Long Term Storage:-20°C
Use/Stability:Stable for at least 1 year after receipt when stored at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Handling:Protect from light.
Technical Info/Product Notes:Note: Product is not sterile
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Product Literature References

Characterization and pharmacological modulation of soluble phospholipase A2 generated during glycogen-induced rat peritonitis: L.A. Marshall, et al.; Agents Actions 37, 60 (1992), Abstract;
PAF and LTB4 biosynthesis in the human neutrophil: effects of putative inhibitors of phospholipase A2 and specific inhibitors of 5-lipoxygenase: K.B. Glaser, et al.; Agents Actions 34, 89 (1991), Abstract;
Luffariellolide, an anti-inflammatory sesterterpene from the marine sponge Luffariella spp.: K.F. Albizati, et al.; Experientia 43, 949 (1987),

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