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RHC-80267

Diacylglycerol lipase inhibitor
 
BML-ST300-0010 10 mg 66.00 USD
 
BML-ST300-0050 50 mg 265.00 USD
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Replaces Prod. #: ALX-270-172

Diacylglycerol (DAG) is an important cellular source of arachidonate which may be released by the action of DAG lipase. RHC-80267 selectively inhibits DAG lipase activity in canine platelets (IC50=4 µM), bovine adrenal chromaffin cells, human adrenal glomerulosa cells, rat thyroid lobes and pancreatic minilobules.

Product Specification

Alternative Name:U-57908, 1,6-bis-(Cyclohexyloximinocarbonylamino)-hexane
 
Formula:C20H34N4O4
 
MW:394.6
 
CAS:83654-05-1
 
Purity:≥98% (HPLC)
 
Appearance:White to off-white solid.
 
MeltingPoint:118-121°C
 
Solubility:Soluble in DMSO (25mg/ml) or 100% ethanol (25mg/ml).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Use/Stability:Store, as supplied, at room temperature for up to 2 years. Store solutions at -20°C for up to 3 months.
 
BML-ST300 structure
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BML-ST300 structure

Product Literature References

Arachidonic acid release from diacylglycerol in human neutrophils. Translocation of diacylglycerol-deacylating enzyme activities from an intracellular pool to plasma membrane upon cell activation: J. Balsinde, et al.; J. Biol. Chem. 266, 15638 (1991), Abstract;
Arachidonic acid liberated by diacylglycerol lipase is essential for the release mechanism in chromaffin cells from bovine adrenal medulla: B. Rindlisbacher, et al.; J. Neurochem. 54, 1247 (1990), Abstract;
Diacylglycerol provides arachidonic acid for lipoxygenase products that mediate angiotensin II-induced aldosterone synthesis: R. Natarajan, et al.; Biochem. Biophys. Res. Commun. 156, 717 (1988), Abstract;
Inhibitors of diacylglycerol lipase and diacylglycerol kinase inhibit carbamylcholine-stimulated responses in guinea pig pancreatic minilobules: M.C. Sekar & L.E. Hokin; Arch. Biochem. Biophys. 256, 509 (1987), Abstract;
RHC 80267 inhibits thyrotropin-stimulated prostaglandin release from rat thyroid lobes: S. Levasseur, et al.; Prostaglandins 27, 673 (1984), Abstract;
Relative activities of rat and dog platelet phospholipase A2 and diglyceride lipase. Selective inhibition of diglyceride lipase by RHC 80267: C.A. Sutherland & D. Amin; J Biol Chem 257, 14006 (1982), Abstract;

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