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Bryostatin 1

PKC activator
 
BML-ST103-0010 10 µg 141.00 USD
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A structurally unique marine natural product that binds to and activates PKC at picomolar concentrations, but is not a carcinogen or a complete tumor promoter. In many systems it induces only a subset of the responses to PMA and blocks those which it does not induce. It is markedly more potent than PMA for translocating PKCδ and -ε.

Product Specification

Formula:C47H68O17
 
MW:905.0
 
CAS:83314-01-6
 
Purity:≥98% (HPLC)
 
Appearance:White solid to colorless film.
 
Solubility:Soluble in DMSO (25mg/ml) or 100% ethanol (25mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
 
BML-ST103 structure
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BML-ST103 structure

Product Literature References

Differential regulation of protein kinase C isozymes by bryostatin 1 and phorbol 12-myristate 13-acetate in NIH 3T3 fibroblasts: Z. Szallasi, et al.; J. Biol. Chem. 269, 2118 (1994), Abstract;
Bryostatin 1, an activator of protein kinase C, inhibits tumor promotion by phorbol esters in SENCAR mouse skin: H. Hennings, et al.; Carcinogenesis 8, 1343 (1987), Abstract;

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For Research Use Only. Not for use in diagnostic procedures.
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