Bryostatin 1

PKC activator



BML-ST103-0010	10 µg	131.00 USD

A structurally unique marine natural product that binds to and activates PKC at picomolar concentrations, but is not a carcinogen or a complete tumor promoter. In many systems it induces only a subset of the responses to PMA and blocks those which it does not induce. It is markedly more potent than PMA for translocating PKCδ and -ε.

Product Specification

Formula:	C₄₇H₆₈O₁₇

MW:	905.0

Purity:	≥98%

Appearance:	Colorless oil.

CAS:	83314-01-6

Solubility:	Soluble in DMSO (25mg/ml) or 100% ethanol (25mg/ml).

Long Term Storage:	-20°C

Background / Technical Information:	Please click here for the comprehensive product datasheet.

Product Literature References

Differential regulation of protein kinase C isozymes by bryostatin 1 and phorbol 12-myristate 13-acetate in NIH 3T3 fibroblasts: Z. Szallasi, et al.; J. Biol. Chem. 269, 2118 (1994), Abstract;

Bryostatin 1, an activator of protein kinase C, inhibits tumor promotion by phorbol esters in SENCAR mouse skin: H. Hennings, et al.; Carcinogenesis 8, 1343 (1987), Abstract;