Replaces Prod. #: ALX-380-051
Antibiotic. Activates JNK/SAPKs, p38 and MAP kinases but not ERKs leading to the phosphorylation of S6, histone H3 and HMG-14 and the induction of the immediate-early genes c-fos and c-jun. Induces apoptosis in the human monoblastoid cell line. Used at 300 ng/ml. Inhibits peptidyl transferase at higher concentrations. Used in the eradication of bean mildew. Inhibits other pathogenic fungi in plants.
Product Details
| Alternative Name: | 2-(p-Methoxybenzyl)-3,4-pyrrolidinediol-3-acetate |
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| Formula: | C14H19NO4 |
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| MW: | 265.3 |
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| Source: | Isolated from Streptomyces griseolus. |
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| CAS: | 22862-76-6 |
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| MI: | 14: 670 |
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| RTECS: | BZ9800000 |
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| Purity: | ≥97% (TLC) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in DMSO (25mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
p38 MAPK regulates the Wnt inhibitor Dickkopf-1 in osteotropic prostate cancer cells: A.J. Browne, et al.; Cell Death Dis.
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Application(s): Cell culture,
Abstract;
Anisomycin abrogates repression of protooncogene c-fos transcription in E1A + cHa-ras-transformed cells through activation of MEK/ERK kinase cascade: A. N. Kukushkin, et al.; J. Cell. Biochem.
103, 1005 (2008),
Abstract;
A chemical screen identifies anisomycin as an anoikis sensitizer that functions by decreasing FLIP protein synthesis: I.A. Mawji, et al.; Cancer Res.
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Abstract;
Anisomycin and the reconsolidation hypothesis: J.W. Rudy, et al.; Learn. Mem.
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Abstract;
Downregulation of Ski and SnoN co-repressors by anisomycin: A. Vazquez-Macias, et al.; FEBS Lett.
579, 3701 (2005),
Abstract;
Anisomycin treatment paradigm affects duration of long-term potentiation in slices of the amygdala: P. Okulski, et al.; Neuroscience
114, 1 (2002),
Abstract;
Anisomycin selectively desensitizes signalling components involved in stress kinase activation and fos and jun induction: C.A. Hazzalin, et al.; Mol Cell Biol
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Abstract;
Growth-dependent translation of IGF-II mRNA by a rapamycin-sensitive pathway: F.C. Nielsen, et al.; Nature
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Abstract;
Neither ERK nor JNK/SAPK MAP kinase subtypes are essential for histone H3/HMG-14 phosphorylation or c-fos and c-jun induction: E. Cano, et al.; J. Cell Sci.
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Abstract;
Protein synthesis inhibitors reveal differential regulation of mitogen-activated protein kinase and stress-activated protein kinase pathways that converge on Elk-1: R. Zinck, et al.; Mol. Cell. Biol.
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Abstract;
Anisomycin and rapamycin define an area upstream of p70/85S6k containing a bifurcation to histone H3-HMG-like protein phosphorylation and c-fos-c-jun induction: E. Kardalinou, et al.; Mol. Cell. Biol.
14, 1066 (1994),
Abstract;
Protein synthesis inhibitor phase shifts vasopressin rhythms in long- term suprachiasmatic cultures: K. Shinohara & T. Oka; NeuroReport
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Abstract;
Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun: I. Sanchez, et al.; Nature
372, 794 (1994),
Abstract;
The stress-activated protein kinase subfamily of c-Jun kinases: J.M. Kyriakis, et al.; Nature
369, 156 (1994),
Abstract;
DNA fragmentation and cytolysis in U937 cells treated with diphtheria toxin or other inhibitors of protein synthesis: S.K. Kochi & R.J. Collier; Exp. Cell. Res.
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Abstract;
Anisomycin, a new anti-protozoan antibiotic: B. A. Sobin & F. W. Tanner; J. Am. Chem. Soc. 76, 4053 (1954),
