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FTY-720 . HCl

S1P receptor ligand
 
BML-SL233-0005 5 mg 76.00 USD
 
BML-SL233-0025 25 mg 311.00 USD
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Replaces Prod. #: ALX-420-043

Novel immune modulator that alters migration and homing of lymphocytes. Acts as a potent agonist of sphingosine 1-phosphate receptors (S1P) after phosphorylation by sphingosine kinase. Also inhibits cytosolic phospholipase A2 independently of sphingosine 1-phosphate receptors.

Product Specification

Alternative Name:2-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol . HCl, Fingolimod . HCl
 
Formula:C19H33NO2 . HCl
 
MW:307.4 . 36.5
 
CAS:162359-56-0
 
Purity:≥98% (HPLC)
 
Identity:Determined by NMR.
 
Appearance:White solid.
 
Solubility:Soluble in DMSO (10mg/ml), 100% ethanol or dimethyl formamide.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
 
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420-043 01

Product Literature References

The Sphingosine 1-Phosphate Receptor Agonist FTY720 Potently Inhibits Regulatory T Cell Proliferation In Vitro and In Vivo: A.M. Wolf, et al.; J. Immunol. 183, 3751 (2009), Abstract;
FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphocytic leukemia: P. Neviani, et al.; J. Clin. Invest. 117, 2408 (2007), Abstract; Full Text
The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors: S.G. Payne, et al.; Blood 109, 1077 (2007), Abstract;
The immune modulator FTY720 targets sphingosine 1-phosphate receptors: V. Brinkmann, et al.; J. Biol. Chem. 277, 21453 (2002), Abstract; Full Text

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