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Fumonisin B2

Ceramide synthase inhibitor
 
BML-SL219-0001 1 mg 222.00 USD
 
BML-SL219-0005 5 mg 934.00 USD
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Replaces Prod. #: ALX-350-237

Mycotoxin, structurally similar to fumonisin B1 (Prod. No. BML-SL220). Found as contaminant mostly in corn silage; was detected recently for the first time in the industrially important Aspergillus niger. Induces cancer. Inducer of apoptosis. Inhibits sphinganine N-acyltransferase (ceramide synthase) at IC50 = 0.1µM. Inhibits de novo sphingolipid biosynthesis.

Product Specification

Formula:C34H59NO14·3H2O
 
MW:759.9
 
CAS:116355-84-1
 
MI:14: 4289 (Fumonisin B1)
 
RTECS:TZ8335000
 
Purity:≥70% (TLC)
 
Appearance:Off-white solid.
 
Solubility:Soluble in water (25mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
 
ALX-350-237
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ALX-350-237

Product Literature References

Mycotoxin occurrence on baled and pit silages collected in Co. Meath: C. McElinney, et al.; Irish J. Agr. Food. Res. 54, 87 (2015), Application(s): Liquid chromatography tandem mass spectrometry for Mycotoxin analysis, Full Text
Fumonisin B2 Production by Aspergillus niger: J.C. Frisvad, et al.; J. Agric. Food Chem. 55, 9727 (2007), Abstract;
Liquid chromatographic determination of fumonisins B1, B2, and B3 in corn silage: E.K. Kim, et al.; J. Agric. Food Chem. 52, 196 (2004), Abstract;
Fumonisins and Alternaria alternata lycopersici toxins: sphinganine analog mycotoxins induce apoptosis in monkey kidney cells: H. Wang, et al.; PNAS 93, 3461 (1996), Abstract;
Fumonisins: fungal toxins that shed light on sphingolipid function: A.H. Merrill, et al.; Trends Cell Biol 6, 218 (1996), Abstract;
Liquid chromatographic determination of the mycotoxin fumonisin B2 in physiological samples: G.S. Shephard, et al.; J. Chromatogr. A 692, 39 (1995), Abstract;
Biological activities of fumonisins, mycotoxins from Fusarium moniliforme, in jimsonweed (Datura stramonium L.) and mammalian cell cultures: H.K. Abbas, et al.; Toxicon 31, 345 (1993), Abstract;
Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme: E. Wang, et al.; J. Biol. Chem. 266, 22 (1991), Abstract;

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