Replaces Prod. #: ALX-350-237
Mycotoxin, structurally similar to fumonisin B1 (Prod. No. BML-SL220). Found as contaminant mostly in corn silage; was detected recently for the first time in the industrially important Aspergillus niger. Induces cancer. Inducer of apoptosis. Inhibits sphinganine N-acyltransferase (ceramide synthase) at IC50 = 0.1µM. Inhibits de novo sphingolipid biosynthesis.
Product Details
Formula: | C34H59NO14 |
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MW: | 705.8 |
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CAS: | 116355-84-1 |
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MI: | 14: 4289 (Fumonisin B1) |
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RTECS: | TZ8335000 |
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Purity: | ≥98% (TLC) |
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Appearance: | Off-white solid. |
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Solubility: | Soluble in water (25mg/ml). |
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Shipping: | Ambient Temperature |
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Long Term Storage: | -20°C |
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Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C. |
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Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Mycotoxin occurrence on baled and pit silages collected in Co. Meath: C. McElinney, et al.; Irish J. Agr. Food. Res.
54, 87 (2015),
Application(s): Liquid chromatography tandem mass spectrometry for Mycotoxin analysis,
Full Text
Fumonisin B2 Production by Aspergillus niger: J.C. Frisvad, et al.; J. Agric. Food Chem.
55, 9727 (2007),
Abstract;
Liquid chromatographic determination of fumonisins B1, B2, and B3 in corn silage: E.K. Kim, et al.; J. Agric. Food Chem.
52, 196 (2004),
Abstract;
Fumonisins and Alternaria alternata lycopersici toxins: sphinganine analog mycotoxins induce apoptosis in monkey kidney cells: H. Wang, et al.; PNAS
93, 3461 (1996),
Abstract;
Fumonisins: fungal toxins that shed light on sphingolipid function: A.H. Merrill, et al.; Trends Cell Biol
6, 218 (1996),
Abstract;
Liquid chromatographic determination of the mycotoxin fumonisin B2 in physiological samples: G.S. Shephard, et al.; J. Chromatogr. A
692, 39 (1995),
Abstract;
Biological activities of fumonisins, mycotoxins from Fusarium moniliforme, in jimsonweed (Datura stramonium L.) and mammalian cell cultures: H.K. Abbas, et al.; Toxicon
31, 345 (1993),
Abstract;
Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme: E. Wang, et al.; J. Biol. Chem.
266, 22 (1991),
Abstract;