Replaces Prod. #: ALX-306-025
An abundant molecular species of endogenous ceramide. It induces phosphorylation of epidermal growth factor receptor on Thr669 in A-431 cells by stimulation of ceramide-activated protein kinase and activates NF-κB at concentrations as low as 50 nM. Activates PKCζ.
Product Details
| Alternative Name: | N-Palmitoyl-D-erythro-sphingosine, N-Hexadecanoyl-D-erythro-sphingosine, N-Palmitoyl ceramide |
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| Formula: | C34H67NO3 |
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| MW: | 537.9 |
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| CAS: | 24696-26-2 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | Solid. |
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| Solubility: | Soluble in 100% ethanol (5mg/ml warm). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Cholesterol-pyrene as a probe for cholesterol distribution on ordered and disordered membranes: Determination of spectral wavelengths: C. Almeida, et al.; PLoS One
13, e0201373 (2018),
Abstract;
Full Text
PKC zeta is a molecular switch in signal transduction of TNF-alpha, bifunctionally regulated by ceramide and arachidonic acid: G. Muller, et al.; EMBO J.
14, 1961 (1995),
Abstract;
Protein kinase C zeta isoform is critical for kappa B-dependent promoter activation by sphingomyelinase: J. Lozano, et al.; J. Biol. Chem.
269, 19200 (1994),
Abstract;
Characterization of a ceramide-activated protein kinase: stimulation by tumor necrosis factor alpha: S. Mathias, et al.; Proc. Natl. Acad. Sci. USA
88, 10009 (1991),
Abstract;
