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C8 Ceramide

Ceramide-activated protein kinase activator
 
BML-SL112-0005 5 mg 61.00 USD
 
BML-SL112-0025 25 mg 242.00 USD
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Replaces Prod. #: ALX-306-013

A biologically active, cell-permeable, but nonphysiologic ceramide analog. It induces phosphorylation of epidermal growth factor receptor on Thr-669 in A-431 cells by stimulation of ceramide-activated protein kinase and induces apoptosis.

Product Specification

Formula:C26H51NO3
 
MW:425.7
 
CAS:74713-59-0
 
Purity:≥98% (TLC)
 
Appearance:White waxy solid.
 
Solubility:Soluble in DMSO (25mg/ml) or 100% ethanol (25mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
 
BML-SL112 structure
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BML-SL112 structure

Product Literature References

Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway: W.D. Jarvis, et al.; PNAS 91, 73 (1994), Abstract;
Activation of the sphingomyelin signaling pathway in intact EL4 cells and in a cell-free system by IL-1 beta: S. Mathias, et al.; Science 259, 519 (1993), Abstract;
Characterization of a ceramide-activated protein kinase: stimulation by tumor necrosis factor alpha: S. Mathias, et al.; PNAS 88, 10009 (1991), Abstract;

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