Replaces Prod. #: ALX-306-013
A biologically active, cell-permeable, but nonphysiologic ceramide analog. It induces phosphorylation of epidermal growth factor receptor on Thr-669 in A-431 cells by stimulation of ceramide-activated protein kinase and induces apoptosis.
Product Details
| Formula: | C26H51NO3 |
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| MW: | 425.7 |
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| CAS: | 74713-59-0 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | White waxy solid. |
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| Solubility: | Soluble in DMSO (25mg/ml) or 100% ethanol (25mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway: W.D. Jarvis, et al.; PNAS
91, 73 (1994),
Abstract;
Activation of the sphingomyelin signaling pathway in intact EL4 cells and in a cell-free system by IL-1 beta: S. Mathias, et al.; Science
259, 519 (1993),
Abstract;
Characterization of a ceramide-activated protein kinase: stimulation by tumor necrosis factor alpha: S. Mathias, et al.; PNAS
88, 10009 (1991),
Abstract;
