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TRAIL (soluble) (mouse), (recombinant)

 
BML-SE722-0100 100 µg 379.00 USD
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Product Specification

Alternative Name:Apo-2L, TNFSF 10, CD253
 
MW:23 kDa
 
Source:Produced in E. coli. Soluble mouse TRAIL (aa 118-291).
 
UniProt ID:P50591
 
Formulation:Liquid. In PBS containing 0.1mM DTT.
 
Purity:≥95% (SDS-PAGE)
 
Purity Detail:Purified by multi-step chromatography.
 
Endotoxin Content:<0.1 EU/µg TRAIL, determined using chromogenic Limulus amebocyte lysate (LAL) test.
 
Biological Activity:Induces apoptosis at 0.1 and 1.0µg/ml, in primary cultured mouse hepatocytes, in the presence of cycloheximide (5µg/ml) or actinomycin D (0.5µg/ml). Induces apoptosis in Jurkat cells (a TRAIL-sensitive human cell line) at 1µg/ml, within 3 hours. Inhibits secondary clonal expansion of mouse CD8+ T cells in vitro (50ng/ml and greater).
 
Shipping:Shipped on Dry Ice
 
Long Term Storage:-80°C
 
Scientific Background:Ligand for TRAIL receptor (DR4, DR5).
 
BML-SE722 SDS-PAGE
SDS-PAGE Analysis: Lane 1: MW Marker, Lane 2: 2 µg TRAIL.
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BML-SE722 SDS-PAGE

Product Literature References

Targeting Immune Privilege to Prevent Pathogenic Neovascularization: J. Roychoudhury, et al.; Invest. Ophthalmol. Vis. Sci. 51, 3560 (2010), Application(s): Intravitreal injections in mice for studies on choroidal neovascularization, Abstract; Full Text
Bortezomib treatment and regulatory T-cell depletion enhance the antitumor effects of adoptively infused NK cells: A. Lundqvist, et al.; Blood 113, 6120 (2009), Application(s): Death induction of sensitized Renca cells, Abstract; Full Text
IRF-5 Is a Mediator of the Death Receptor-induced Apoptotic Signaling Pathway: G. Hu & B.J. Barnes; J. Biol. Chem. 284, 2767 (2009), Application(s): Death induction of HCT116 cells, Abstract; Full Text
Treating Metastatic Solid Tumors With Bortezomib and a Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Receptor Agonist Antibody: A. Shanker, et al.; J. Natl. Cancer Inst. 100, 649 (2008), Application(s): Death induction of sensitized Renca, TBJ, 4T1 cells, Abstract; Full Text
The role of NF-κB-1 and NF-κB-2-mediated resistance to apoptosis in lymphomas: L. Bernal-Mizrachi, et al.; PNAS 103, 9220 (2006), Application(s): Death induction of 204-3-1, NK-H and NK-92 cells and analysis of resistance to TRAIL-induced cell death of Daudi, SC, F8 and BLA cells, Abstract; Full Text
Keratins Modulate c-Flip/Extracellular Signal-Regulated Kinase 1 and 2 Antiapoptotic Signaling in Simple Epithelial Cells: S. Gilbert, et al.; Mol. Cell Biol. 24, 7072 (2004), Application(s): Death induction of sensitized mouse primary hepatocytes, Abstract; Full Text
TRAIL and KILLER Are Expressed and Induce Apoptosis in the Murine Preimplantation Embryo: J.K. Riley, et al.; Biol. Reprod. 71, 871 (2004), Application(s): Death induction of sensitized mice blastocysts, Abstract; Full Text
The proteasome inhibitor PS-341 sensitizes neoplastic cells to TRAIL-mediated apoptosis by reducing levels of c-FLIP: T.J. Sayers, et al.; Blood 102, 303 (2003), Application(s): Death induction of sensitized C1498 and Renca cells and sensitized C1498-bone marrow cocultures in mice, Abstract; Full Text
Roles of TNF-Related Apoptosis-Inducing Ligand in Experimental Autoimmune Encephalomyelitis: B. Hilliard, et al.; J. Immunol. 15, 166 (2001), Application(s): Death induction of L929 cells, Abstract; Full Text

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