Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

PRL-3 (human), (recombinant) (His-tag)

BML-SE558-0050 50 µg 367.00 USD
Do you need bulk/larger quantities?

Product Specification

Alternative Name:Phosphatase of regenerating liver 3, Protein tyrosine phosphatase type IVA 3
Source:Produced in E. coli. The catalytic domain of PRL-3 (aa 2-173) is fused at the N-terminus to a His-tag.
UniProt ID:O75365
Formulation:Liquid. In 40mM TRIS-HCl, pH 8.0, containing 110mM sodium chloride, 2.2mM potassium chloride, 20% glycerol, and 3mM dithiothreitol.
Purity:≥90% (SDS-PAGE)
Specific Activity:0.774U/μg. One unit will hydrolyze 1pmol para-nitrophenyl phosphate (PNPP) per minute at 37°C. Assay buffer: 50mM TRIS, pH 7.4, containing 150mM sodium chloride, 5mM dithiothreitol and 12.5mM PNPP.
Application Notes:Useful for studies of enzyme kinetics and regulation, dephosphorylation of target substrates, and inhibitor screening.
Shipping:Shipped on Dry Ice
Long Term Storage:-80°C
Use/Stability:Dilution of the enzyme followed by refreezing may lead to loss of activity.
Scientific Background:PRL phosphatases comprise a class of small oncogenic phosphatases that are prenylated at their carboxyl-termini. PRL-3 is overexpressed in colon tumors metastasizing to the liver, but not in normal colorectal epithelium. Metastatic lesions have also shown gene amplification of the PRL-3 gene. PRL-3-blocking antibodies reduce metastatic tumor formation by cells overexpressing PRL-3.

General Literature References

Monoclonal antibodies target intracellular PRL phosphatases to inhibit cancer metastases in mice: K. Guo, et al.; Cancer Biol. Ther. 7, 750 (2008), Abstract; Full Text
A phosphatase associated with metastasis of colorectal cancer: S. Saha, et al.; Science 294, 1343 (2001), Abstract;

Product Toolbox


Certificate of Analysis


By target:
By biological activity:
PRL Recombinant protein
PRL Enzyme
PTP Recombinant protein
PTP Enzyme
By catalog section:


Technical Service
Customer Service

Recommend this page

For Research Use Only. Not for use in diagnostic procedures.
Keep in touch

©2018 Enzo Life Sciences, Inc.,