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RAP (human), (recombinant)

 
BML-SE552-0100 100 µg 321.00 USD
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Product Specification

Alternative Name:LDL receptor associated protein, LRPAP1, LDL receptor-related protein-associated protein 1
 
MW:~39kDa (SDS-PAGE)
 
Source:Produced in E. coli.
 
UniProt ID:P30533
 
Formulation:Liquid. In 0.0067M Phosphate, pH 7.4 containing 0.15M sodium chloride.
 
Purity:≥90% (SDS-PAGE)
 
Application Notes:Useful tool for binding studies, and testing in vivo and in cell culture.
 
Shipping:Shipped on Dry Ice
 
Long Term Storage:-80°C
 
Handling:Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C.
 
Scientific Background:RAP functions in ER maturation of lipoprotein receptor family members by acting as an antagonist. It blocks binding of PCSK9 to lipoprotein receptors and of all known ligands (including MMP-9 and apoE) to lipoprotein receptor-related protein 1 (LRP-1). Modulates amyloid deposition in mouse models of Alzheimer’s disease. Reduces endocytosis of prion protein (PrPc) by neuronal cells.
 

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