[R¹¹²A, R¹¹³G]Brain derived neurotrophic factor precursor (mouse), (recombinant)

Trk ligand

Alternative Name:	pro-BDNF

Purity:	>99%

Source/Host:	Produced in E. coli.

Application:	Growth and differentiation factor for neuronal cultures, receptor binding studies.

Miscellaneous/General:	BDNF is a neurotrophic factor expressed by proteolytic cleavage of its precursor, proBDNF. The precursor form was thought to be important for the correct folding, secretion and trafficking of the mature protein. Processes such as neuronal process retraction and neuronal apoptosis were thought to be mediated by the binding of BDNF to p75. The finding that proBDNF, and not mature BDNF, is the preferred ligand for p756 has led to a reexamination of the biological roles of the two forms. The amino acid sequence of proBDNF-mut has been changed to prevent the proteolytic cleavage which results in the formation of mature BDNF.

Background / Technical Information:	Please click here for the comprehensive product datasheet.