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Procathepsin F (human), (recombinant)

 
BML-SE541-0005 5 µg 328.00 USD
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Product Specification

MW:39 kDa
 
Source:Produced in insect cells. Glycosylated procathepsin F.
 
EC:3.4.22.41
 
UniProt ID:Q9UBX1
 
Formulation:Liquid. In 20mM NaOAc, pH 5.0, 2.5mM EDTA, 250mM NaCl.
 
Purity Detail:Partially purified by single-step affinity chromatography and gel filtration.
 
Activity:Under acidic conditions (pH 4.0 optimum), procathepsin F self-cleaves to its 30 kDa active form. Procathepsin F can also be activated with pepsin. This can be monitored by SDS-PAGE, or by activity using Z-Phe-Arg-AMC (Prod. No. BML-P139) or Z-Leu-Arg-AMC (Prod. No. BML-P229) at 10µM in 100mM NaOAc, pH 5.75, 1mM EDTA, 10mM L-cysteine.
 
Shipping:Shipped on Dry Ice
 
Long Term Storage:-80°C
 
Scientific Background:Cathepsin F, a member of the papain family of lysosomal cysteine proteases, acts upon proteins such as MHC Class II-associated invariant chain and ApoB-1006. It is inhibited by the cysteine proteinase inhibitor E-643 and cystatin C4. It is a lysosomal protease expressed in numerous tissues, notably brain and macrophages. It functions in the immune system and is implicated in disease states such as atherosclerosis, cancer, and angiogenesis.
 

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