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PDE10A (catalytic domain) (rat), (recombinant)

 
BML-SE526-0020 20 µg 424.00 USD
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Product Specification

Alternative Name:Phosphodiesterase 10A
 
MW:37 kDa
 
Source:Produced in insect cells. Active catalytic domain of phosphodiesterase 10A. Produced in a baculovirus expression system.
 
UniProt ID:Q9QYJ6
 
Application Notes:Useful for kinetic and functional studies, phosphorylation of target substrates, drug screening.
 
Shipping:Shipped on Dry Ice
 
Long Term Storage:-80°C
 
Scientific Background:This enzyme can hydrolyze both cAMP and cGMP, but has a higher affinity for cAMP. In the brain it is present in neuronal cell bodies and neuropil of the striatum, in striatonigral and striatopallidal white matter tracks, and in the substantia nigra and globus pallidus. Outside the brain it is found in the testis, epididymal sperm, and enteric ganglia1. It is under investigation as a drug target for schizophrenia and diabetes.
 

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