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TrkA (human), (recombinant) (GST-tag)

 
BML-SE518-0005 5 µg 263.00 USD
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Product Specification

Alternative Name:High affinity nerve growth factor receptor, Tyrosine kinase receptor A, Tropomyosin-related receptor, Neurotrophic tyrosine kinase receptor type 1
 
MW:66 kDa
 
Source:Produced in insect cells. Active enzyme (aa 440- end) is fused at the N-terminus to a GST-tag. Produced in a baculovirus expression system.
 
UniProt ID:P04629
 
Shipping:Shipped on Dry Ice
 
Long Term Storage:-80°C
 
Scientific Background:TRKA is a member of the trk proto-oncogene family and encodes a 140 kilodalton, membrane-spanning protein tyrosine kinase that is the functional receptor for nerve growth factor (NGF). NGF elicits the rapid phosphorylation of gp140trk on tyrosine residues leading to increased c-Fos expression, DNA synthesis and morphologic transformation. The major pathways activated by the Trk receptors are Ras, Rac, PI 3-kinase, PLC-γ1 and their downstream effectors. These include Ras stimulation of MAP kinase cascades, PI 3-kinase stimulation of Akt and PLC-γ1-dependent generation of IP3 and diacylglycerol (DAG) that results in mobilization of Ca2+ and activation of Ca2+ and DAG-regulated protein kinases.
 

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