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MEK1 (human), (recombinant) (His-tag)

BML-SE509-0020 20 µg 412.00 USD
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Product Specification

Alternative Name:MAPK2K1, MAPKK1, MAP kinase kinase 1, MAPK/ERK kinase 1
Source:Produced in E. coli. Active full length MEK1 (MAPK2K1) with C- and N-terminal His-tags. Genbank ID No. NM_002755.
UniProt ID:Q02750
Formulation:Liquid. In 50mM TRIS-HCl, pH 8.0, containing 150mM sodium chloride, 5mM DTT, 0.03% Brij-35, 20% glycerol.
Purity:≥85% (SDS-PAGE)
Purity Detail:Purified by multi-step chromatography.
Specific Activity:≥12 pmol/min/µg. Kinase activity was measured using the non-radioactive ADP Hunter Plus kit™.
Application Notes:Useful tool to study enzyme regulation and kinetics, phosphorylate target substrates, screen for inhibitors.
Shipping:Shipped on Dry Ice
Long Term Storage:-80°C
Use/Stability:After initial defrost, aliquot product into individual tubes and refreeze at -80°C. Avoid repeated freeze/defrost cycles.
Scientific Background:MEK1 is a dual-specificity kinase that phosphorylates ERK1/2, activating it in response to extracellular and intracellular signals. It also acts to downregulate PPAR γ by a direct interaction that results in PPAR γ moving into the cytoplasm from the nucleus.

General Literature References

Differential regulation and properties of MAPKs.: M. Raman et al.; Oncogene 26, 3100 (2007),
Interaction with MEK causes nuclear export and downregulation of peroxisome proliferator-activated receptor gamma.: E. Burgermeister et al.; Mol. Cell Biol. 27, 803 (2007),

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