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HDAC6 (human), (recombinant) (His-tag)

Highly active
 
BML-SE508-0050 50 µg 424.00 USD
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Product Specification

Alternative Name:Histone deacetylase 6
 
MW:131 kDa
 
Source:Produced in insect cells.
 
UniProt ID:Q9UBN7
 
Gene/Protein Identifier:NM_006044 (RefSeq)
 
Formulation:Liquid. In 50mM TRIS, pH 8.0, 138 mM NaCl and 10% glycerol.
 
Purity Detail:Partially purified by single-step affinity chromatography and gel filtration.
 
Biological Activity:Active with various fluorogenic peptide substrates, including FLUOR DE LYS® deacetylase substrate (Prod. No. BML-KI104) and FLUOR DE LYS®-SIRT1 deacetylase substrate (Prod. No. BML-KI177).
 
Specific Activity:≥1 U/µg. One U=1 pmol/min at 37°C, 100 µM, FLUOR DE LYS®-SIRT1 deacetylase substrate (Prod. No. BML-KI177).
 
Shipping:Shipped on Dry Ice
 
Long Term Storage:-80°C
 
Scientific Background:HDAC6 is a class II HDAC, a group defined by its member’s homology to the yeast HDAC HDA1. It is unique among human HDACs in that it contains two full deacetylase domains. A tubulin deacetylase, HDAC6 may act to promote autophagic clearing of huntingtin aggregates and retard HIV1 infection, but also to promote invasive motility in tumor cells.
 
BML-SE508 SDS-PAGE
SDS-PAGE analysis: Lane 1: MW marker, Lane 2: 2µg HDAC6.
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BML-SE508 SDS-PAGE

Product Literature References

4-(1-Ethyl-4-anisyl-imidazol-5-yl)-N-hydroxycinnamide–A new pleiotropic HDAC inhibitor targeting Cancer cell signalling and cytoskeletal organisation: K. Mahal, et al.; Exp. Cell Res. 336, 263 (2015), Application(s): HDAC Assay, Abstract;
Tasquinimod is an allosteric modulator of HDAC4 survival signaling within the compromised cancer microenvironment: J.T. Isaacs, et al.; Cancer Res. 73, 1386 (2012), Abstract;
Tubulin acetylation alone does not affect kinesin-1 velocity and run length in vitro: W.J. Walter, et al.; PLoS One 7, e42218 (2012), Abstract; Full Text
Cutting edge: tubulin a functions as an adaptor in NFAT-importin b interaction: K. Ishiguro, et al.; J. Immunol. 186, 2710 (2011), Abstract; Full Text
Synthesis and evaluation of aliphatic-chain hydroxamates capped with osthole derivatives as histone deacetylase inhibitors: W.H. Huang, et al.; Eur. J. Med. Chem. 46, 4042 (2011), Abstract;

Related Products

FLUOR DE LYS® deacetylase substrate 

Highly sensitive and convenient alternative to radiolabeled, acetylated histones or peptide/HPLC methods for the assay of histone deacetylases.
≥95% (HPLC) | Print as PDF
 
BML-KI104-0050 50 µl 162.00 USD
Do you need bulk/larger quantities?
 

FLUOR DE LYS®-SIRT1 deacetylase substrate 

≥95% (HPLC) | Print as PDF
 
BML-KI177-0005 0.5 µmol 200.00 USD
Do you need bulk/larger quantities?
 

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