Product Details
| Alternative Name: | Histone deacetylase 3 |
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| MW: | 49 kDa |
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| Source: | Produced in insect cells. Produced in a baculovirus expression system. |
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| UniProt ID: | O15379 |
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| Gene/Protein Identifier: | NM_003883 (RefSeq) |
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| Formulation: | Liquid. In 50mM TRIS, pH 8.0, 138 mM NaCl and 10% glycerol. |
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| Purity Detail: | Partially purified by single-step affinity chromatography and gel filtration. |
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| Specific Activity: | ≥0.7 U/µg. One U=1 pmol/min at 37°C, 100 µM, FLUOR DE LYS®-SIRT1 deacetylase substrate (Prod. No. BML-KI177). |
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| Shipping: | Dry Ice |
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| Long Term Storage: | -80°C |
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| Scientific Background: | HDAC3, although a class I HDAC and has been assigned to its own phylogenetic subclass and its caspase-dependent cleavage and relocation to the cytoplasm may be critical to the progression of apoptosis, implying an important role in pathways affecting heart disease. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Novel hydroxamic acid derivative induces apoptosis and constrains autophagy in leukemic cells: M.A. Fischer, et al.; J. Adv. Res. (2023),
Abstract;
Design, Synthesis, and biological evaluation of HDAC6 inhibitors based on Cap modification strategy: X. Li, et al.; Bioorg. Chem.
125, 105874 (2022),
Abstract;
Mitotic Activation of a Novel Histone Deacetylase 3-Linker Histone H1.3 Complex by Protein Kinase CK2: H. Patil, et al.; J. Biol. Chem.
291, 3158 (2016),
Application(s): Pull down assay,
Abstract;
Full Text
Tasquinimod is an allosteric modulator of HDAC4 survival signaling within the compromised cancer microenvironment: J.T. Isaacs, et al.; Cancer Res.
73, 1386 (2012),
Abstract;
Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis: M.M. Mihaylova, et al.; Cell
145, 607 (2011),
Abstract;
Full Text
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