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p38 (human), (recombinant) (His-tag)

 
BML-SE499-0020 20 µg 395.00 USD
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Product Specification

Alternative Name:MAPK14, MAP kinase 14
 
MW:~41kDa
 
Source:Produced in insect cells. Active full length p38α (MAPK14) is fused at the N-terminus to a His-tag.
 
UniProt ID:Q16539
 
Gene/Protein Identifier:NM_139012 (RefSeq)
 
Formulation:Liquid. In 20mM TRIS/HCl, pH 8.0, 200mM NaCl, 5mM DTT, 0.1 % Tween-20, 10% glycerol.
 
Purity:≥90% (SDS-PAGE)
 
Purity Detail:Purified by multi-step chromatography.
 
Specific Activity:≥1 pmol/min/µg. Kinase activity was measured using the non-radioactive ADP Hunter Plus kit™.
 
Application Notes:Useful to study enzyme regulation and kinetics, phosphorylate target substrates, screen for inhibitors.
 
Shipping:Shipped on Dry Ice
 
Long Term Storage:-80°C
 
Handling:Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C.
 
Scientific Background:p38 is a member of the MAP kinase family and is activated by environmental stresses and some pro-inflammatory cytokines. This kinase is known to phosphorylate ATF2, ELK1, MEF2A, MAX, CDC25B, p53, and also some downstream kinases, such as MK2, MK3, PRAK, MNK1/2, and MSK1.These substrates implicate p38 in stress related transcription and cell cycle regulation. Several p38 inhibitors are in clinical trials for the treatment of chronic obstructive pulmonary disease, psoriasis, and rheumatoid arthritis.
 

General Literature References

Crystal structure of the p38 alpha-MAPKAP kinase 2 heterodimer: E. ter Haar, et al.; J. Biol. Chem. 282, 9733 (2007), Abstract; Full Text

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