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PKCα (human), (recombinant) (GST-tag)

BML-SE494-0005 5 µg 171.00 USD
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Product Specification

Alternative Name:Protein kinase Cα
MW:103 kDa
Source:Produced in insect cells. Full length active PKCa (protein kinase C α) is fused at the N-terminus to a GST-tag. Produced in a baculovirus expression system.
UniProt ID:P17252
Application Notes:Useful for kinetic and functional studies, phosphorylation of target substrates, drug screening.
Shipping:Shipped on Dry Ice
Long Term Storage:-80°C
Scientific Background:PKCα is a member of the PKC family of serine- and threonine-specific protein kinases that can be activated by calcium and diacylglycerol. It has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca2+ handling in myocytes.

Product Literature References

Cardiac RKIP induces a beneficial β-adrenoceptor-dependent positive inotropy: E. Schmid, et al.; Nat. Med. 21, 1298 (2015), Application(s): In vitro phosphorylation of RKIP by PKC, Abstract; Full Text

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