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14-3-3σ (human), (recombinant) (His-tag)

BML-SE488-0100 100 µg 299.00 USD
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Product Specification

MW:~30 kDa
Source:Produced in E. coli. Human 14-3-3s is fused at the C-terminus to a His-tag.
UniProt ID:P31947
Formulation:Liquid. In 50mM NaH2PO4, pH 8.0, 300mM NaCl.
Purity:≥90% (SDS-PAGE)
Purity Detail:Purified by multi-step chromatography.
Shipping:Shipped on Dry Ice
Long Term Storage:-80°C
Scientific Background:14-3-3 proteins are dimeric phosphoserine/phosphothreonine binding proteins, which have been shown to be involved in the regulation of many crucial processes such as signal transduction, cell-cycle control, apoptosis, protein localization, phosphorylation state and stability, transcription, metabolism, and malignant transformation. 14-3-3σ is the main 14-3-3 isoform that has been directly implicated in the development of cancer. The 14-3-3σ gene is directly regulated by p53 and is silenced by CpG methylation in a large number of carcinomas.

General Literature References

C-TAK1 interacts with microphthalmia-associated transcription factor, Mitf, but not the related family member Tfe3: T. Schwarz, et al.; BBRC 394, 890 (2010), Abstract;

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