Product Specification
| MW: | ~30 kDa |
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| Purity: | >90% (SDS-PAGE) |
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| Source/Host: | Produced in E. coli. Human 14-3-3ζ is fused at the C-terminus to a His-tag. |
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| Application: | Drug screening, protein-protein interaction studies, gel overlays. |
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| Long Term Storage: | -80°C |
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| Miscellaneous/General: | 14-3-3 proteins are dimeric phosphoserine/phosphothreonine binding proteins, which have been shown to be involved in the regulation of many crucial processes such as signal transduction, cell-cycle control, apoptosis, protein localization, phosphorylation state and stability, transcription, metabolism, and malignant transformation. 14-3-3ζ has been shown to be present in brain amyloid plaques. It has also been hypothesized that 14-3-3ζ is recruited by cells to form protein aggregates with misfolded proteins in order to protect the cell against toxicity. |
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| Background / Technical Information: | Please click here for the comprehensive product datasheet. |
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General Literature References
C-TAK1 interacts with microphthalmia-associated transcription factor, Mitf, but not the related family member Tfe3: T. Schwarz, et al.; BBRC
394, 890 (2010),
Abstract;