14-3-3ε (human), (recombinant) (His-tag)



BML-SE484-0100	100 µg	237.00 USD

Product Specification

MW:	~30 kDa

Purity:	>90% (SDS-PAGE)

Source/Host:	Produced in E. coli. Human 14-3-3ε is fused at the C-terminus to a His-tag.

Application:	Drug screening, protein-protein interaction studies, gel overlays.

Long Term Storage:	-80°C

Miscellaneous/General:	14-3-3 proteins are dimeric phosphoserine/phosphothreonine binding proteins, which have been shown to be involved in the regulation of many crucial processes such as signal transduction, cell-cycle control, apoptosis, protein localization, phosphorylation state and stability, transcription, metabolism, and malignant transformation. 14-3-3ε is implicated in an early left-right patterning in amphibian embryos. In addition, children with Miller-Dieker syndrome, a severe brain malformation associated with mental retardation, have heterozygous deletions of both the 14-3-3%epsilon; and LIS1 genes. It has also been shown to be the only 14-3-3 isoform associated with prion protein amyloid deposits of Gerstmann-Straussler-Scheinker disease.

Background / Technical Information:	Please click here for the comprehensive product datasheet.

SDS-PAGE analysis. Lane 1: MW Marker, Lane 2: 1 µg, Lane 3: 2 µg, Lane 4: 5 µg 14-3-3ε.

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General Literature References

C-TAK1 interacts with microphthalmia-associated transcription factor, Mitf, but not the related family member Tfe3: T. Schwarz, et al.; BBRC 394, 890 (2010), Abstract;