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Cystatin C (human), (purified)

Protease inhibitor
 
BML-SE479-0100 100 µg 195.00 USD
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Product Specification

Alternative Name:Cystatin-3, Neuroendocrine basic polypeptide
 
MW:~13kDa
 
Source:Isolated from human urine.
 
UniProt ID:P01034
 
Formulation:Lyophilized from 0.02M ammonium bicarbonate buffer.
 
Purity:≥95% (SDS-PAGE)
 
Application Notes:Can be used for the inhibition of cysteine protease activity or of amyloid fibril formation in vitro, in vivo, or in tissue culture. 
 
Reconstitution:Resuspend in water and freeze at -20ºC in aliquots.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Use/Stability:Although this is in highly purified form, and the source individual tested negative for all diseases tested, handle this product with all due precautions.
 
Handling:Aliquot product into individual tubes and freeze at -20 or -70°C. Avoid freeze/thaw cycles.
 
Scientific Background:Cystatin C is a major member of a large family of endogenous cysteine protease inhibitors found throughout the body. It inhibits proteases such as cathepsin B, H, DPPI, and papain, and is inactivated by neutrophil elastase. It is involved in cancer, rheumatoid arthritis, and other inflammatory diseases, and serves as a marker for renal function. Recently it was shown to bind and inhibit amyloid fibril formation, indicating therapeutic potential for Alzheimer’s disease.
 

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