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MKP-3/p38 (human), (recombinant)

BML-SE455-0100 100 µg 404.00 USD
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Approximately 1:1 stoichiometric complex of MKP-3 with p38α.

Product Specification

Alternative Name:MAP kinase phosphatase 3/p38, DUSP6/p38, Dual specificity protein phosphatase 6/p38, PYST1/p38
MW:42 kDa / 41 kDa
Source:Produced in Sf9 insect cells. Produced in a baculovirus expression system.
UniProt ID:Q16828 (MKP3)
Formulation:Liquid. In 20mM TRIS/HCl, pH 8.0, 200mM NaCl, 5mM DTT, 0.1 % Tween-20, 10% glycerol.
Purity:≥90% (SDS-PAGE)
Purity Detail:Purified by multi-step chromatography.
Specific Activity:≥10 U/µg assayed by 3-O-methyl fluorescein phosphate (OMFP) hydrolysis at 30°C.
Shipping:Shipped on Dry Ice
Long Term Storage:-80°C
Scientific Background:MKP-3 (MAP Kinase Phosphatase-3, DUSP-6, PYST1) has an N-terminal MAP kinase binding domain. Co-expressing MKP-3 with p38 MAP kinase results in increased phosphatase activity compared to MKP-3 expressed alone.

General Literature References

Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity: G. Li, et al.; Nature Medicine (2012), Abstract;

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MKP-3 (human), (recombinant) 

Produced in Sf9 insect cells. Recombinant full length MKP-3. Produced in a baculovirus expression system. | Print as PDF
BML-SE454-0100 100 µg 407.00 USD
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