| Alternative Name: | MAP kinase phosphatase 3, DUSP6, Dual specificity protein phosphatase 6, PYST1 |
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| MW: | 42 kDa |
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| Source: | Produced in Sf9 insect cells. Recombinant full length MKP-3. Produced in a baculovirus expression system. |
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| UniProt ID: | Q16828 |
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| Gene/Protein Identifier: | NM_001946 (RefSeq) |
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| Formulation: | Liquid. In 20mM TRIS/HCl, pH 8.0, 200mM NaCl, 5mM DTT, 0.1 % Tween-20, 10% glycerol. |
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| Purity Detail: | Partially purified by single-step affinity chromatography and gel filtration. |
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| Specific Activity: | ≥10 U/mg assayed by 3-O-methyl fluorescein phosphate (OMFP) hydrolysis at pH 8.2, 30°C. One unit is equal to 1 nmole phosphate hydrolyzed from OMFP per minute. |
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| Shipping: | Dry Ice |
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| Long Term Storage: | -80°C |
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| Scientific Background: | MKP-3 is a member of a group of dual specificity phosphatases which negatively regulate MAP kinases, dephosphorylating both the phosphotyrosine and phosphothreonine in the pTXpY activation loop motif. Transcriptional suppression of MKP-3 expression has been implicated in the development of pancreatic cancer. MKP-3 is located in the nucleus where it may act to anchor Erk 1/2. |
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| Regulatory Status: | RUO - Research Use Only |
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