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MKP-1 (human), (recombinant)

 
BML-SE439-0100 100 µg 404.00 USD
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Product Specification

Alternative Name:MAP kinase phosphatase-1, DUSP1, CL100
 
MW:39 kDa
 
Source:Produced in Sf9 cells. Recombinant full length MKP-1.
 
UniProt ID:P28562
 
Gene/Protein Identifier:NM_004417 (RefSeq)
 
Formulation:Liquid. In 20mM TRIS/HCl, pH 8.0, 200mM NaCl, 5mM DTT, 0.1 % Tween-20, 10% glycerol.
 
Purity Detail:Partially purified by single-step affinity chromatography and gel filtration.
 
Specific Activity:≥10 U/mg assayed by 3-O-methyl fluorescein phosphate (OMFP) hydrolysis at pH 8.2, 30°C. One unit is equal to 1 nmole phosphate hydrolyzed from OMFP per minute.
 
Shipping:Shipped on Dry Ice
 
Long Term Storage:-80°C
 
Scientific Background:MKP-1 is the founding exemplar of a group of dual specificity phosphatases which negatively regulate the MAP Kinases, dephosphorylating both the phosphotyrosine and the phosphothreonine in the -pTXpY- activation-loop motif. MKP-1 is implicated primarily in the inactivation of the stress-responsive p38 and JNK MAP kinase. Studies indicate that MKP-1 is the anti-inflammatory target of glucocorticoids in human endothelium.
 

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