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PKA C-α (human), (recombinant) (GST-tag)

BML-SE410-0005 5 µg 262.00 USD
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Product Specification

Alternative Name:cAMP-dependent protein kinase catalytic subunit α, Protein kinase A C-α
MW:69 kDa
Source:Produced in insect cells. Full length active enzyme fused at the N-terminus to a GST-tag. Produced in a baculovirus expression system.
UniProt ID:P17612
Shipping:Shipped on Dry Ice
Long Term Storage:-80°C
Scientific Background:Most of the effects of cAMP in the eukaryotic cell are mediated through the phosphorylation of target proteins on serine or threonine by the cAMP-dependent protein kinase. The inactive cAMP-dependent protein kinase is a tetramer composed of 2 regulatory and 2 catalytic subunits. The cooperative binding of 4 molecules of cAMP dissociates the enzyme in a regulatory subunit dimer and 2 free active catalytic subunits. Null mutations in PKAca leads to early postnatal death in the majority of C-α knock out mice.

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