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PKCδ (human), (recombinant) (GST-tag)

 
BML-SE346-0005 5 µg 168.00 USD
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Product Specification

Alternative Name:Protein kinase C δ
 
MW:104 kDa
 
Source:Produced in insect cells. Active, full length protein kinase C δ (PKCd).
 
UniProt ID:Q05655
 
Formulation:Liquid. In 50mM TRIS-HCl, pH 7.5, containing 150mM sodium chloride, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF and 25% glycerol.
 
Application Notes:Useful for kinetic and functional studies, phosphorylation of target substrates, drug screening.
 
Shipping:Shipped on Dry Ice
 
Long Term Storage:-80°C
 
Scientific Background:PKCδ was the first novel PKC isozyme discovered. It is calcium-insensitive, but still activated by DAG and phorbol esters. Cleavage by caspase 3 results in the activation of PKCδ and translocation of the catalytic domain into the mitochondrion. This cleavage and activation is associated with inhibition of cell cycle progression and induction of apoptosis by UV and ionizing radiation, cisplatin, etoposide, cytosine arabinoside, mitomycin C and doxorubicin.
 
Technical Info/Product Notes:Replacement for ADI-PPK-465
 

Product Literature References

Cardiac RKIP induces a beneficial β-adrenoceptor-dependent positive inotropy: E. Schmid, et al.; Nat. Med. 21, 1298 (2015), Application(s): In vitro phosphorylation of RKIP by PKC, Abstract; Full Text

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