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p70 S6 kinase (human), (recombinant)

BML-SE345-0005 5 µg 264.00 USD
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Product Specification

Alternative Name:p70 S6K
MW:71 kDa
Source:Produced in insect cells. Active, full length p70 S6K. Produced in a baculovirus expression system.
UniProt ID:P23443 (S6K1), Q9UBS0 (S6K2)
Formulation:Liquid. In 50mM sodium phosphate, pH 7.0, containing 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, and 25% glycerol.
Application Notes:Useful for Useful for kinetic and functional studies, phosphorylation of target substrates, drug screening.
Shipping:Shipped on Dry Ice
Long Term Storage:-80°C
Scientific Background:p70 S6K was first identified as the kinase responsible for the phosphorylation of the S6 ribosomal protein. Research has raised the possibility that S6K might, in fact, be the rapamycin-sensitive effector responsible for directly phosphorylating IRS-1 and thereby inhibiting PI 3-kinase activation. Another study suggests that S6K1 activation may mediate some of the effects of a high-fat diet on inhibiting the insulin-PI 3-kinase signaling pathway3. This makes S6K1 a promising new therapeutic target in the fight against type 2 diabetes.
Technical Info/Product Notes:Replacement for ADI-PPK-439

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