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Calmodulin (human), (recombinant)

 
BML-SE325-0001 1 mg 222.00 USD
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Replaces Prod. #: ALX-200-005

Product Specification

Alternative Name:CaM, Phosphodiesterase 3':5'-cyclic nucleotide activator
 
Sequence:Sequence identical to Genbank accession M27319.1.
 
MW:16.8 kDa
 
Source:Produced in E. coli.
 
CAS:73298-54-1
 
MI:14: 1719
 
UniProt ID:P62158
 
Formulation:Lyophilized. Salt-free.
 
Purity:≥95% (SDS-PAGE)
 
Purity Detail:Purified by multi-step chromatography.
 
Biological Activity:Elicits Ca2+-dependent activation of calcineurin (Ca2+/calmodulin-dependent Ser/Thr protein phosphatase 2B, PP-2B) with the same potency and to the same maximum extent as purified native calmodulin.
 
Application Notes:Calmodulin can be used to activate calmodulin-dependent phosphodiesterase, calcineurin, CaM kinases, etc.
 
Reconstitution:Reconstitute in water or an appropriate buffer.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Handling:Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
 
BML-SE325 SDS-PAGE
SDS-PAGE Analysis: Lane 1: MW Marker; Lane 2: 1.0 µg of purified human recombinant calmodulin protein (Prod. No. BML-SE325).
BML-SE325 activation
Human recombinant calmodulin (Prod. No. BML-SE325) activation of human calcineurin is essentially identical to that of purified bovine brain calmodulin (native, bovine). Initial rates of calcineurin phosphatase activity were determined as a function of calmodulin concentration with the Calcineurin Colorimetric Drug Discovery Kit (Prod. No. BML-AK804). (Note that the human and bovine calmodulin amino acid sequences are 100% identical.)
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BML-SE325 SDS-PAGE BML-SE325 activation

Product Literature References

A model for regulation by SynGAP-α1 of binding of synaptic proteins to PDZ-domain 'Slots' in the postsynaptic density: W.G. Walkup, et al.; Elife 5, e22495 (2016), Application(s): Measurement of affinity of CaM for r-synGAP-a1 by SPR, Abstract; Full Text
The phosphatase calcineurin regulates pathological TDP-43 phosphorylation: N.F. Liachko, et al.; Acta Neuropathol. 4, 545 (2016), Abstract;
Dissecting cooperative communications in a protein with a high-throughput single-molecule scalpel: Z. Yu, et al.; Chemphyschem. 16, 223 (2015), Abstract;

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