Calmodulin (human), (recombinant)



BML-SE325-0001	1 mg	194.00 USD

Replaces Prod. #: ALX-200-005

Product Specification

Alternative Name:	CaM, Phosphodiesterase 3':5'-cyclic nucleotide activator

MW:	16.8 kDa

Purity:	≥98% (SDS-PAGE)

Sequence:	Sequence identical to Genbank accession M27319.1.

Formulation:	Lyophilized. Salt-free.

Biological Activity:	Elicits Ca²⁺-dependent activation of calcineurin (Ca²⁺/calmodulin-dependent Ser/Thr protein phosphatase 2B, PP-2B) with the same potency and to the same maximum extent as purified native calmodulin.

CAS:	73298-54-1

MI:	14: 1719

Source/Host:	Produced in E. coli.

Reconstitution:	Reconstitute in water or an appropriate buffer.

Application:	Calmodulin can be used to activate calmodulin-dependent phosphodiesterase, calcineurin, CaM kinases, etc.

Long Term Storage:	-20°C

Handling:	After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.

Background / Technical Information:	Please click here for the comprehensive product datasheet.

SDS-PAGE Analysis: Lane 1: MW Marker; Lane 2: 1.0 µg of purified human recombinant calmodulin protein (Prod. No. BML-SE325).

Human recombinant calmodulin (Prod. No. BML-SE325) activation of human calcineurin is essentially identical to that of purified bovine brain calmodulin (native, bovine). Initial rates of calcineurin phosphatase activity were determined as a function of calmodulin concentration with the Calcineurin Colorimetric Drug Discovery Kit (Prod. No. BML-AK804). (Note that the human and bovine calmodulin amino acid sequences are 100% identical.)

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