14-3-3σ (human), (recombinant) (GST-tag)

MW:	~60 kDa

Source/Host:	Produced in E. coli. Human 14-3-3σ is fused at the N-terminus to a GST-tag.

Application:	Protein-protein interaction studies, gel overlays.

Long Term Storage:	-80°C

Miscellaneous/General:	14-3-3 proteins are dimeric phosphoserine/phosphothreonine binding proteins, which have been shown to be involved in the regulation of many crucial processes such as signal transduction, cell-cycle control, apoptosis, protein localization, phosphorylation-state and stability, transcription, metabolism, and malignant transformation. 14-3-3s is the main 14-3-3 isoform that has been directly implicated in the development of cancer. The 14-3-3s gene is directly regulated by p53 and is silenced by CpG methylation in a large number of carcinomas.

Background / Technical Information:	Please click here for the comprehensive product datasheet.