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PTP-IA2 (catalytic domain) (human), (recombinant) (GST-tag)

BML-SE278-0020 20 µg Inquire for pricing
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Product Specification

Alternative Name:ICA512, Protein tyrosine phosphatase IA2
MW:~58.8 kDa
Source:Produced in E. coli. The catalytic domain of human PTP-IA2 (aa 693-970) is fused at the N-terminus to a GST-tag.
UniProt ID:Q16849
Formulation:Liquid. In 25mM TRIS-HCl, pH 8.0, containing 75mM sodium chloride, 0.05% Tween-20, 50% glycerol, 2mM EDTA, 1mM dithiothreitol and 10mM glutathione.
Purity:≥90% (SDS-PAGE)
Shipping:Shipped on Blue Ice
Long Term Storage:-20°C
Scientific Background:IA2, together with IAR, form a subgroup of receptor-like protein tyrosine phosphatases. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. It is highly expressed in neuroendocrine tissues.

General Literature References

Localization of the genes encoding the type I diabetes autoantigens, protein-tyrosine phosphatases IA2 and IAR: G. Morahan, et al.; Mamm. Genome 9, 593 (1998), Abstract;
Islet cell antigen 512 is a diabetes-specific islet autoantigen related to protein tyrosine phosphatases: D.U. Rabin, et al.; J. Immunol. 152, 3183 (1994), Abstract;

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