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IκBα (human), (recombinant)

 
BML-SE263-0025 25 µg 191.00 USD
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Product Specification

MW:36 kDa
 
Source:Produced in E. coli. Human full length recombinant IκB&alpha (aa 1-317).
 
UniProt ID:P25963
 
Application Notes:Useful for phosphorylation and kinetic studies, drug screening.
 
Shipping:Shipped on Dry Ice
 
Long Term Storage:-80°C
 
Scientific Background:Phosphorylation of IκBα on serines 32 and 36 targets it for degradation by the ubiquitin/proteasome pathway and can be detected using a phosphospecific IκBα (pSer32, pSer36) antibody. This degradation of IκBα causes the release of NF-κB, which then moves into the nucleus where it activates transcription of a variety of genes.
 

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For Research Use Only. Not for use in diagnostic procedures.
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