IκBα (human), (recombinant)

MW:	36 kDa

Source/Host:	Produced in E. coli. Human full length recombinant IκB&alpha (aa 1-317).

Application:	Phosphorylation and kinetic studies, drug screening.

Long Term Storage:	-80°C

Miscellaneous/General:	Phosphorylation of IκBα on serines 32 and 36 targets it for degradation by the ubiquitin/proteasome pathway and can be detected using a phosphospecific IκBα (pSer³², pSer³⁶) antibody. This degradation of IκBα causes the release of NF-κB, which then moves into the nucleus where it activates transcription of a variety of genes.

Background / Technical Information:	Please click here for the comprehensive product datasheet.