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SIRT2 (human), (recombinant) (His-tag)

 
BML-SE251-0500 500 U 404.00 USD
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Product Specification

Alternative Name:Sirtuin 2
 
MW:43 kDa
 
Source:Produced in E. coli. Contains a N-terminal His-tag.
 
UniProt ID:Q8IXJ6
 
Formulation:Liquid. In 25mM TRIS, pH 7.5, containing 100mM NaCl, 5mM DTT and 10% glycerol.
 
Purity Detail:Purified by multi-step chromatography.
 
Specific Activity:One unit will deacetylate 1pmol/min of FLUOR DE LYS®-SIRT2 substrate (Prod. No. BML-KI179).
 
Shipping:Shipped on Dry Ice
 
Long Term Storage:-80°C
 
Scientific Background:Due to their roles in gene silencing, aging, and oxidative stress responses, the sirtuins (NAD. Like Sir2, human SIRT2 is a class I sirtuin, although not as closely related to Sir2 and human SIRT1 and its catalytic core has the same basic two-domain architecture and central groove as other sirtuinsand an interaction with the homeobox transcription factor HOXA10.
 

Product Literature References

Role of deleted in breast cancer 1 (DBC1) protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase: V. Nin, et al.; J. Biol. Chem. 287, 23489 (2012), Abstract; Full Text

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