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SIRT1 (human), (recombinant) (His-tag)

Highly active
 
BML-SE239-0100 100 U 334.00 USD
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Product Specification

Alternative Name:Sirtuin 1
 
MW:82 kDa
 
Source:Produced in E. coli. Recombinant SIRT1 from human cDNA containing an N-terminal His-tag.
 
UniProt ID:Q96EB6
 
Gene/Protein Identifier:NM_012238 (RefSeq)
 
Formulation:Liquid. In 25 mM TRIS, pH 7.5, 100mM NaCl, 5mM DTT and 10% glycerol.
 
Purity Detail:Partially purified by single-step affinity chromatography and gel filtration.
 
Specific Activity:One unit = 1pmol/min at 37°C, 250µM FLUOR DE LYS® substrate (Prod. No. BML-KI104), 500µM NAD+.
 
Shipping:Shipped on Dry Ice
 
Long Term Storage:-80°C
 

Product Literature References

AROS has a context-dependent effect on SIRT1: T. Kokkola, et al.; FEBS Lett. 588, 1523 (2014), Application(s): In vitro activity assay, Abstract;
Cytotoxicity and cell death mechanisms induced by a novel bisnaphthalimidopropyl derivative against the NCI-H460 non-small lung cancer cell line: R.T. Lima, et al.; Anticancer Agents Med. Chem. 13, 414 (2013), Abstract;
Regulation of inositol 1,3,4-trisphosphate 5/6-kinase (ITPK1) by reversible lysine acetylation: C. Zhang, et al.; Proc. Natl. Acad. Sci U.S.A. 109, 2290 (2012), Abstract; Full Text
Role of deleted in breast cancer 1 (DBC1) protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase: V. Nin, et al.; J. Biol. Chem. 287, 23489 (2012), Abstract; Full Text
A brain-permeable small molecule reduces neuronal cholesterol by inhibiting activity of sirtuin 2 deacetylase: D.M. Taylor, et al.; ACS Chem. Biol. 6, 540 (2011), Abstract;
SIRT1 is a redox-sensitive deacetylase that is post-translationally modified by oxidants and carbonyl stress: S. Caito, et al.; FASEB J. 24, 3145 (2010), Application(s): Mass spectrometry analysis of SIRT1 modified by reactive aldehydes, Abstract; Full Text

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FLUOR DE LYS® deacetylase substrate 

Highly sensitive and convenient alternative to radiolabeled, acetylated histones or peptide/HPLC methods for the assay of histone deacetylases.
≥95% (HPLC) | Print as PDF
 
BML-KI104-0050 50 µl 162.00 USD
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