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Granzyme B (human), (recombinant)

 
BML-SE238-5000 5000 U 404.00 USD
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Product Specification

MW:25.4 kDa
 
Source:Produced in yeast. Recombinant human granzyme B (aa 21-247).
 
UniProt ID:P10144
 
Concentration:100 U/µl
 
Formulation:Liquid. In 50mM TRIS, pH 7.4, 100mM NaCl, 10% glycerol.
 
Purity Detail:Partially purified by single-step affinity chromatography and gel filtration.
 
Biological Activity:A serine protease with caspase-like substrate specificity.
 
Specific Activity:One unit hydrolyzes 1 pmol/min of Ac-IEPD-pNA (200 µM, Prod. No. BML-P133) at 30°C.
 
Shipping:Shipped on Dry Ice
 
Long Term Storage:-80°C
 
Scientific Background:Granzyme B is a component of the cytolytic granules of cytotoxic T lymphocytes and natural killer cells.
 

Product Literature References

Development of autoantibodies against muscle-specific FHL1 in severe inflammatory myopathies: I. Albrecht, et al.; J. Clin. Invest. 125, 4612 (2015), Application(s): Skeletal muscle cell culture, Abstract; Full Text
Enhanced expression of PD L1 in cervical intraepithelial neoplasia and cervical cancers: L. Mezache, et al.; Mod. Pathol. 28, 1594 (2015), Application(s): Immunohistochemistry, Abstract;
Measurement of Cellular Immunity to Influenza Vaccination in Rheumatoid Arthritis; Comparison of Three Assays: N. Madar-Balakirski, et al.; J. Vaccines Vaccin. 6, 1000278 (2015), Application(s): Activity Assay, Full Text

Related Products

Ac-IEPD-pNA 

Caspase substrate
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BML-P133-0005 5 mg 142.00 USD
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