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Cathepsin B (human liver), (purified)

Highly pure lysosomal protease
 
BML-SE198-0025 25 µg 235.00 USD
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Product Specification

MW:~27.5 kDa
 
Source:Purified from human liver.
 
UniProt ID:P07858
 
Formulation:Liquid. In 50mM sodium acetate, pH 5.0, containing 1mM EDTA.
 
Purity:≥95% (SDS-PAGE)
 
Application Notes:Useful for inhibitor screening, kinetic studies and cleavage of substrates in vitro or in tissue culture.
 
Shipping:Shipped on Dry Ice
 
Long Term Storage:-80°C
 
Scientific Background:Cathepsin B is a lysosomal protease (endopeptidase and dipeptidyl carboxypeptidase) that can also be secreted from the cell and is involved in protein degradation, apoptosis, arthritis, cancer, and Alzheimer’s disease.
 

Product Literature References

A mechanistic model to predict effects of cathepsin B and cystatin C on β-amyloid aggregation and degradation: T.J. Perlenfein, et al.; J. Biol. Chem. 292, 21071 (2017), Abstract; Full Text
Doxorubicin impairs cardiomyocyte viability by suppressing transcription factor EB expression and disrupting autophagy: J.J. Bartlett, et al.; Biochem. J. 473, 3769 (2016), Abstract;
Expression, purification, and characterization of human cystatin C monomers and oligomers: T.J. Perlenfein, et al.; Protein Expr. Purif. 117, 35 (2016), Abstract; Full Text
Glucolipotoxicity diminishes cardiomyocyte TFEB and inhibits lysosomal autophagy during obesity and diabetes: P.C. Trivedi, et al.; Biochim. Biophys. Acta 1861, 1893 (2016), Abstract;
Development of a highly potent, selective, and cell-active Inhibitor of cysteine cathepsin L-A hybrid design approach: D. Dana, et al.; Chem. Commun. (Camb.) 50, 10875 (2014), Abstract;
Development of cell-active non-peptidyl inhibitors of cysteine cathepsins: D. Dana, et al.; Bioorg. Med. Chem. 21, 2975 (2013), Application(s): Assay, Abstract;
Mechanisms of Dendritic Cell Lysosomal Killing of Cryptococcus: C.R. Hole, et al.; Sci. Rep. 2, 739 (2012), Application(s): Cell Culture, Abstract; Full Text

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