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Cathepsin B (human liver), (purified)

Highly pure lysosomal protease
 
BML-SE198-0025 25 µg 224.00 USD
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Product Specification

MW:~27.5 kDa
 
Source:Purified from human liver.
 
UniProt ID:P07858
 
Formulation:Liquid. In 50mM sodium acetate, pH 5.0, containing 1mM EDTA.
 
Purity:≥95% (SDS-PAGE)
 
Application Notes:Useful for inhibitor screening, kinetic studies and cleavage of substrates in vitro or in tissue culture.
 
Shipping:Shipped on Dry Ice
 
Long Term Storage:-80°C
 
Scientific Background:Cathepsin B is a lysosomal protease (endopeptidase and dipeptidyl carboxypeptidase) that can also be secreted from the cell and is involved in protein degradation, apoptosis, arthritis, cancer, and Alzheimer’s disease.
 

Product Literature References

Development of a highly potent, selective, and cell-active Inhibitor of cysteine cathepsin L-A hybrid design approach: D. Dana, et al.; Chem. Commun. (Camb.) 50, 10875 (2014), Abstract;
Development of cell-active non-peptidyl inhibitors of cysteine cathepsins: D. Dana, et al.; Bioorg. Med. Chem. 21, 2975 (2013), Application(s): Assay, Abstract;
Mechanisms of Dendritic Cell Lysosomal Killing of Cryptococcus: C.R. Hole, et al.; Sci. Rep. 2, 739 (2012), Application(s): Cell Culture, Abstract; Full Text

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