Product Details
| MW: | 23 + 10 kDa subunits |
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| Source: | Produced in E. coli. Mouse caspase-11 (aa 81-373). |
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| UniProt ID: | P70343 |
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| Formulation: | Liquid. In 50mM HEPES, pH 7.4, 100mM NaCl, 0.5% CHAPS, 1 mM EDTA, 10% glycerol, 10mM DTT. |
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| Purity: | ≥95% (SDS-PAGE) |
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| Activity: | 100 U/µl |
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| Specific Activity: | One unit hydrolyzes 1 pmol/min of Ac-WEHD-pNA (500 µM, Prod. No. ALX-260-082) at 30°C. |
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| Shipping: | Dry Ice |
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| Long Term Storage: | -80°C |
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| Scientific Background: | A member of the caspase-1 subfamily, caspase-11 is the possible homolog of human caspase-4. Its expression is highly inducible, in various mouse tissues, by LPS injection. |
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| Regulatory Status: | RUO - Research Use Only |
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SDS-PAGE Analysis: Lane 1: MW Marker, Lane 2: 1 μg, Lane 2: 2 μg Caspase-11.
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Product Literature References
Cathepsin G inhibition by serpinb1 and serpinb6 prevents programmed necrosis in neutrophils and monocytes and reduces GSDMD-driven inflammation: S.S. Burgener, et al.; Cell Rep.
27, 3646 (2019),
Abstract;
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