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Stauprimide

 
BML-SC106-0001 1 mg 109.00 USD
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Potently increases the efficiency of directed differentiation of mouse and human embryonic stem cells in the presence of Activin A (EC50=0.3µM in Sox17+ /Sox7- cells). Interacts with NME2 and inhibits its nuclear localization leading to downregulation of c-Myc. Under various conditions, stauprimide treated ESC's were able to be differentiated into endoderm, neuronal, and mesoderm cell lines.

Product Specification

Alternative Name:N-Benzoyl-7-oxostaurosporine
 
Formula:C35H28N4O5
 
MW:584.6
 
CAS:154589-96-5
 
Purity:≥98% (HPLC)
 
Appearance:Yellow solid.
 
Solubility:Soluble in DMSO (20 mg/ml).
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 1 year after receipt when stored at -20°C. Solutions can be stored at -20°C for up to 3 months.
 
BML-SC106 Structure scaled
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BML-SC106 Structure scaled

Product Literature References

A Small Molecule Primes Embryonic Stem Cells for Differentiation: S. Zhu, et al.; Cell Stem Cell 4, 416 (2009), Abstract;

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