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Reversine

Aurora kinase inhibitor
 
BML-SC104-0005 5 mg 129.00 USD
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Induces dedifferentiation in murine C2C12 myoblasts. The cells were also shown to regain multipluripotency following removal of the compound. Potent and selective A3 adenosine receptor antagonist (Ki = 0.66µM) and a novel aurora kinase inhibitor (IC50's of 30-550nM for blast colony formation assay).

Product Specification

Alternative Name:2-(4-Morpholinoanilino)-6-cyclohexylaminopurine
 
Formula:C21H27N7O
 
MW:393.5
 
CAS:656820-32-5
 
Purity:≥98% (TLC)
 
Appearance:Pale gray solid.
 
Solubility:Soluble in DMSO (10mg/ml).
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Use/Stability:Store, as supplied, at -20°C for up to 1 year.  Store solutions at -20°C for up to 3 months.
 
BMl-SC104 Structure
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BMl-SC104 Structure

Product Literature References

Probing the catalytic functions of Bub1 kinase using the small molecule inhibitors BAY-320 and BAY-524: A.P. Baron, et al.; eLife 5, e12187 (2016), Application(s): Cell culture, Abstract; Full Text
The NOXA-MCL1-BIM axis defines lifespan on extended mitotic arrest: M.D. Haschka, et al.; Nat. Commun. 6, 6891 (2015), Application(s): Cell Culture, Abstract; Full Text
Reversine, a novel Aurora kinase inhibitor, inhibits colony formation of human myeloid leukemia cells.: A.M. D'Alise, et al.; Mol. Cancer Ther. 7, 1140 (2008), Abstract; Full Text
"Reversine" and it's 2-Substituted Adenine Derivatives as Potent and Selective A3 Adenosine Receptor Antagonists: M. Perreira, et al.; J. Med. Chem. 48, 4910 (2005), Abstract;
Dedifferentiation of Lineage-Committed Cells by a Small Molecule: S. Chen, et al.; JACS 126, 410 (2004), Abstract;

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Aurora kinase
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