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Brain-derived neurotrophic factor polyclonal antibody

 
BML-SA665-0050 50 µl 334.00 USD
 
BML-SA665-0200 200 µl 504.00 USD
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Product Specification

Alternative Name:BDNF
 
Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to aa 166-178 of human BDNF (brain-derived neurotrophic factor). The sequence is conserved in mouse, rat, and many other species.
 
UniProt ID:P23560
 
Species reactivity:Human, Mouse
 
Crossreactivity:Does not cross-react with NGF, NT-3 or NT-4.
 
Applications:ICC, IHC, WB
 
Recommended Dilutions/Conditions:Immunocytochemistry (1:50)
Western blot (1:200)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Purity Detail:Affinity purified.
 
Formulation:Lyophilized from PBS, pH 7.4, containing 1% BSA, and 0.025% sodium azide.
 
Reconstitution:Reconstitute with deionized water either 50µl or 200µl, depending on sample size.
 
Use/Stability:Reconstituted antibody is stable for up to 2 weeks at 4°C. For longer periods aliquot and store at -20°C. For further dilutions use a carrier protein such as BSA (1%).
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:BDNF is a member of the neurotrophin family of growth factors which includes nerve growth factor (NGF), neurotrophin-3 (NT-3) and neurotrophin-4/5 (NT-4/5). BDNF conveys its activity by binding to two classes of receptors, a member of the Trk receptor tyrosine kinase family (TrkB) and the pan-neurotrophin receptor p75NTR. Binding of BDNF to the TrkB receptor triggers ligand-induced dimerization and autophosphorylation of tyrosine residues.
 

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