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A2A Adenosine receptor polyclonal antibody

 
BML-SA654-0050 50 µl 334.00 USD
 
BML-SA654-0200 200 µl 528.00 USD
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Product Specification

Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to aa 201-215 of mouse A2AAR (A2A adenosine receptor).
 
UniProt ID:Q60613
 
Species reactivity:Human, Mouse, Rat
 
Applications:IHC, WB
 
Positive Control:Included.
 
Formulation:Lyophilized from PBS, pH 7.4, containing 1% BSA and 0.05% sodium azide.
 
Reconstitution:Antibody: Reconstitute with 50µl of deionized water for BML-SA654-0050. Reconstitute with 200µl deionized water for BML-SA654-0200. This will yield a 0.75mg/ml concentration.
Control peptide: Reconstitute with 100µl of deionized water.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:Adenosine is an endogenous nucleoside generated locally in tissues under conditions of hypoxia, ischemia, or inflammation. It modulates a variety of physiological functions in many tissues including brain and heart. It exerts its action via four specific adenosine receptors (also named P1 purinergic receptors): A1 Adenosine Receptor (A1AR), A2A Adenosine Receptor (A2AAR), A2B Adenosine Receptor (A2BAR), and A3 Adenosine Receptor (A3AR). All are integral membrane proteins and members of the G Protein-Coupled Receptor superfamily. The various adenosine receptors can be distinguished on the basis of their differential selectivity for adenosine analogs. Adenosine receptors control neurotransmitter release through the facilitatory A2AAR and the inhibitory A1AR. A2AAR and A1AR are the major adenosine receptor subtypes expressed in the central nervous system. A2AAR is mainly expressed in the striatum on GABAergic striatopallidal neurons, while A1AR is widely distributed throughout the CNS.
 

Product Literature References

Antagonism of adenosine A2A receptor expressed by lung adenocarcinoma tumor cells and cancer associated fibroblasts inhibits their growth: M. Mediavilla-Varela, et al.; Cancer Biol Ther 14, 860 (2013), Application(s): Western Blot, Immunohistochemistry, Abstract; Full Text
Selective adenosine A2A receptor agonists and antagonists protect against spinal cord injury through peripheral and central effects: I. Paterniti, et al.; J. Neuroinflammation 8, 31 (2011), Application(s): Western blot, Abstract; Full Text

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