A2A Adenosine receptor, pAb

Adenosine is an endogenous nucleoside generated locally in tissues under conditions of hypoxia, ischemia, or inflammation. It modulates a variety of physiological functions in many tissues including brain and heart^{1, 2}. It exerts its action via four specific adenosine receptors (also named P1 purinergic receptors): A₁ Adenosine Receptor (A1AR), A_2A Adenosine Receptor (A2AAR), A_2B Adenosine Receptor (A2BAR), and A₃ Adenosine Receptor (A3AR). All are integral membrane proteins and members of the G Protein-Coupled Receptor superfamily.