Product Specification
| Alternative Name: | MC2R |
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| Host: | Rabbit |
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| Immunogen: | Synthetic peptide corresponding to aa 87-99 of human MC2R (melanocortin receptor 2). |
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| UniProt ID: | Q01718 |
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| Species reactivity: | Human, Rat
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| Applications: | IHC, WB
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| Blocking Peptide: | Included. Synthetic peptide corresponding to aa 87-99 of human MC2R (melanocortin receptor 2). Lyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C. Reconstitute with 100µl water and store at -20°C. Use 1µg peptide per 1μg antibody.
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| Purity Detail: | Affinity purified. |
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| Formulation: | Lyophilized from PBS, pH 7.4, containing 1% BSA and 0.05% sodium azide. |
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| Shipping: | Shipped on Blue Ice |
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| Long Term Storage: | -20°C |
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| Scientific Background: | The melanocortin receptors are members of the G protein-coupled receptor superfamily. Their ligands, the melanocortins, are peptides consisting of α-, β- and γ-melanocyte stimulating hormone and adrenocorticotropic hormone. MC2R is only activated by ACTH. It is expressed gene is expressed in skin, scalp tissue, compound nevus tissue, basal cell carcinoma tissue, and cultured melanocytes. |
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Product Literature References
Expression of melanocortin receptors in human prostate cancer cell lines: MC2R activation by ACTH increases prostate cancer cell proliferation: S. Hafiz, et al.; Int. J. Oncol.
41, 1373 (2012),
Application(s): Immunofluorescence,
Abstract;
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