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AT2 receptor (extracellular) polyclonal antibody

BML-SA609-0050 50 µl 310.00 USD
BML-SA609-0200 200 µl 529.00 USD
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Product Specification

Alternative Name:Angiotensin II receptor type 2
Immunogen:Synthetic peptide corresponding to aa 21-35 of rat AT2.
UniProt ID:P35351
Species reactivity:Mouse, Rat
Formulation:Lyophilized from PBS, pH 7.4, 1% BSA and 0.025% sodium azide.
Shipping:Shipped on Blue Ice
Long Term Storage:-20°C
Scientific Background:Angiotensin II receptor type 2 or AT2 is one of the receptors that binds the octapeptide hormone Angiotensin II (Ang II). Most of the physiological actions of Ang II are mediated by AT1 a member of the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily. AT2 is also a GPCR, and is largely believed to have counter-regulatory roles to the ones exerted through the AT1 receptor. Hence, binding of Ang II to the AT2 receptor will result in growth arrest and apoptosis, vasodilatation and hypotension. Although the AT2 receptor is structurally a member of the GPCR superfamily, the signaling mechanisms elicited following AT2 receptor activation are not fully clarified. Research indicates that the AT2 receptor signals through the Gia2 and the Gia3 proteins and through the activation of phosphotyrosine phosphatases such as SHP-1. The AT2 receptor distribution is more restricted than that of the AT1 receptor. The highest expression levels of AT2 have been found in the fetus, which is followed by a marked decrease shortly after birth. Nevertheless, significant AT2 receptor expression can be detected in the heart, kidney, vascular endothelial cells and brain.
bml-sa609 wb1
Image 1: Western blot of rat brain membranes: Lane 1. PAb to AT2 Receptor (Extracellular) (Prod. No. BML-SA609), 1:500. Lane 2. PAb to AT2 Receptor (Extracellular), preincubated with the control peptide antigen.
bml-sa609 wb2
Image 2: Western blot of mouse MS1 endothelial cells: Lane 1. PAb to AT2 Receptor (Extracellular) (Prod. No. BML-SA609), 1:400. Lane 2. PAb to AT2 Receptor (Extracellular), preincubated with the control peptide antigen.
bml-sa609 ihc
Image 3: Staining of angiotensin II receptor type-2 (AT2) with PAb to AT2 Receptor (Extracellular) (Prod. No. BML-SA609) in rat brain sections. AT2 receptor is stained red, a Nissl counterstain is in blue. A, AT2 receptor expressing neurons are scattered in the paraventricular nucleus of the hypothalamus (arrows), in the vicinity of the 3rd ventricle (3rd V). B, AT2 receptor expressing neurons in the supraoptic nucleus (arrows), adjacent to the optic nerve.
bml-sa609 icc
Image 4: Immunocytochemical staining of live intact rat GH3 pituitary cells with PAb to AT2 Receptor (Extracellular) (Prod. No. BML-SA609) (1:100), followed by goat-anti-rabbit-AlexaFluor-555 secondary antibody.
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bml-sa609 wb1 bml-sa609 wb2 bml-sa609 ihc bml-sa609 icc

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